Endocrine Abstracts

Introduction: Cushing’s syndrome is rare during pregnancy perhaps because hypersecretion of glucocorticoids supresses pituitary gonadotrophin secretion resulting in subfertility. When present, the syndrome is usually due to adrenal disease and less commonly to pituitary adenomas or ectopic ACTH production. In the contrary, Cushing’s syndrome outside pregnancy is usually due to pituitary adenomas whereas non ACTH-dependent Cushing’s is less frequent.<p class=...

We have earlier shown a reciprocal feed-forward amplification link between expression of transcription factor GATA-4 and luteinizing hormone receptor (LHR) during adrenocortical tumorigenesis, and also that chronically elevated LH levels may induce LHR in mice, but not GATA-4. Hereby, our goal was to analyze the consequences of ectopically expressed GATA-4 on murine adrenal cortex in the presence and absence of gonadectomy (GDX) induced elevated LH levels. For this purpose, we...